Understanding the Side Effects of Semaglutide and Tirzepatide: A Comprehensive Guide for Patients of

Jun 02, 2024
Understanding the Side Effects of Semaglutide and Tirzepatide: A Comprehensive Guide for Patients t Braxton Medical Clinic, L
At Braxton Medical Clinic, LLC, we prioritize your health and well-being. We ensure our patients are well-informed about treatment options, including potential side effects of Semaglutide (Wegovy/Ozempic) and Tirzepatide (Zepbound/Mounjaro). 615-900-1659.

Semaglutide (Wegovy/Ozempic)

Semaglutide is a GLP-1 receptor agonist used primarily for managing type 2 diabetes and, more recently, for chronic weight management. While it has proven benefits, it is essential to be aware of its potential side effects.

Common Side Effects:

  1. Nausea and Vomiting: These are the most frequently reported side effects, particularly when starting the medication or increasing the dose.
  2. Diarrhea: Gastrointestinal disturbances are common, though they often decrease over time.
  3. Constipation: Some patients may experience constipation instead of diarrhea.
  4. Abdominal Pain: Discomfort in the stomach area is possible, sometimes accompanied by bloating.
  5. Decreased Appetite: While this can be beneficial for weight management, it might be uncomfortable for some patients.

Serious Side Effects:

  1. Pancreatitis: Though rare, inflammation of the pancreas is a severe side effect that requires immediate medical attention.
  2. Kidney Problems: There have been reports of acute kidney injury, usually in patients who have experienced significant dehydration.
  3. Gallbladder Issues: Semaglutide can increase the risk of gallbladder disease, including gallstones.
  4. Allergic Reactions: Rash, itching, or difficulty breathing can indicate a serious allergic reaction.

Management Tips:

  • Start Slowly: Gradual dose escalation can help mitigate gastrointestinal side effects.
  • Stay Hydrated: Drinking plenty of fluids can reduce the risk of kidney problems.
  • Monitor Symptoms: Keep track of any unusual symptoms and report them to your healthcare provider promptly.

Tirzepatide (Zepbound/Mounjaro)

Tirzepatide is a dual GIP and GLP-1 receptor agonist, primarily used for managing type 2 diabetes. Its dual-action mechanism offers promising benefits but also comes with potential side effects.

Common Side Effects:

  1. Nausea: Similar to Semaglutide, nausea is common, particularly at the start of treatment.
  2. Vomiting and Diarrhea: Gastrointestinal issues are frequently reported.
  3. Decreased Appetite: Beneficial for some, this can be uncomfortable for others.
  4. Fatigue: Some patients experience unusual tiredness or lack of energy.

Serious Side Effects:

  1. Pancreatitis: As with Semaglutide, there is a risk of pancreatitis.
  2. Hypoglycemia: Especially when combined with other diabetes medications, Tirzepatide can cause low blood sugar levels.
  3. Gallbladder Disease: Increased risk of gallstones and other gallbladder issues.
  4. Thyroid Tumors: Although rare, there have been reports of thyroid C-cell tumors in animal studies.

Management Tips:

  • Diet Adjustments: Eating smaller, more frequent meals can help manage nausea.
  • Monitor Blood Sugar Levels: Regular monitoring is essential to avoid hypoglycemia.
  • Regular Check-ups: Routine medical check-ups can help catch any serious side effects early.


At Braxton Medical Clinic, LLC, we are dedicated to ensuring you receive the best possible care. Understanding the potential side effects of your medications is a crucial part of managing your health. If you are experiencing any side effects or have concerns about your treatment with Semaglutide or Tirzepatide, please contact us at 615-900-1659. Our team is here to support you every step of the way.